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Rapid weight loss from GLP 1 medications like Ozempic can sometimes lead to changes in the buttock area, often called Ozempic Butt. This can include a loss of volume, flatter contour, and looser GLP 1 outcomes: What we've learned and where payers need to focus next How Does Retatrutide Work For Weight Loss? GLP 1 is made in your gut. So when you are on a GLP 1 medication and something isn't working, the gut is usually where I look first. Side effects. Plateaus.